Antimicrobial Resistance MRes

Robert Oakley, St George’s University Hospitals NHS Foundation Trust

I wish to develop my clinical career around antimicrobials/therapeutic drug monitoring (TDM) and undertake associated doctoral/post-doctoral study in this area. I see an exciting gap as a pharmacist, to utilise novel technologies to improve these substantial components of many patients’ care. My informed interest is in reducing inter-patient variability in therapeutic response to vancomycin and associated acute-kidney-injury (AKI) in intensive care unit (ICU) patients. I hypothesise that the vancomycin ‘area-under-the-blood-concentration-curve’ (AUC) TDM methodology is superior to ‘blood-trough-concentration’ TDM in guiding precision dosing in ICU patients, which will optimise clinical outcomes. I also envisage that AUC TDM data can be statistically processed to problem-solve variability issues through TDM personalisation. 

The final report is available to view here.